Teppei Ikeya's Homepage

“Ikumen” is a Japanese term for fathers who actively participate in raising their children. The word combines "ikuji", meaning childcare in Japanese, with the English word “men.” Although traditional Japanese work culture often expected fathers to devote most of their time and energy to their jobs, an increasing number of fathers now take an active role in childcare and enjoy spending time with their children.

I consider myself a true IKEUMEN! As you can see from the photo, I am fully committed to spending time with my daughter.

PUBLICATIONS & BOOKS

1. Paper Development and biological characterization of the cyclic peptide cRGDTFI with potent binding affinity for integrins αvβ3 and αvβ5. Materials & Design 257, 114466 (2025).
2. Paper A Methionine-Rich Repeat Forms a Spiral Conformation That Guides Aragonite Nanofiber Organization in Molluscan Ligaments. Biomacromolecules (2025).
3. Paper Multistate Structure Determination and Dynamics Analysis Reveals a Unique Ubiquitin-Recognition Mechanism in Ubiquitin C-terminal Hydrolase. Journal of the American Chemical Society (2025).
4. Paper Development and Biological Characterization of the Cyclic Peptide Crgdtfi with Potent Binding Affinity for Integrins Αvβ3 and Αvβ5. Social Science Research Network (SSRN) (2025).
5. Paper Backbone and side-chain 1H, 13C and 15N resonance assignments and secondary structure determination of the rhizobial FixJ. Biomolecular NMR Assignments 19, 77–82 (2025).
6. Paper Different molecular recognition by three domains of the full-length GRB2 to SOS1 proline-rich motifs and EGFR phosphorylated sites. Chemical Science 15(38), 15858–15872 (2024).
7. Paper Structure and Dynamics of Drk-SH2 Domain and Its Site-Specific Interaction with Sev Receptor Tyrosine Kinase. International Journal of Molecular Sciences 25(12), 6386 (2024).
8. Paper Structural and Functional Analysis of the Amorphous Calcium Carbonate-Binding Protein Paramyosin in the Shell of the Pearl Oyster, Pinctada fucata. Langmuir 40(16), 8373–8392 (2024).
9. Paper Structural and biochemical insights into heterotetramer formation of oncogenic K-Ras4B^G12V and Rgl2, a RalA/B activator. Life Science Alliance 7(1), e202302080 (2023).
10. Paper Interactions of the N- and C-terminal SH3 Domains of Drosophila Drk with the proline-rich peptides from Sos and Dos. International Journal of Molecular Sciences 24, 14135–14145 (2023).
11. Paper Structural and Functional Analyses of the Acidic and Basic Amino Acid Repeat Sequence (DDRK) in Pif 80 from Pinctada fucata on the Aragonite Crystal Surface Using NMR. Crystal Growth & Design 23(7), 5264–5278 (2023).
12. Paper Protein structural analysis in living cells and for multiple conformations using solution NMR (2023).
13. Paper Insight into the C-terminal SH3 domain mediated binding of Drosophila Drk to Sos and Dos. Biochemical and Biophysical Research Communications 625, 87–93 (2022).
14. Paper Structural insights into the complex of oncogenic KRas4B^G12V and Rgl2, a RalA/B activator. bioRxiv (2022).
15. Paper Molecular mechanism of glycolytic flux control intrinsic to human phosphoglycerate kinase. Proceedings of the National Academy of Sciences 118(50) (2021).
16. Paper Targeting chromosome trisomy for chromosome editing. Scientific Reports 11(1) (2021).
17. Paper Multi-state structure determination and dynamics analysis reveals a new ubiquitin-recognition mechanism in yeast ubiquitin C-terminal hydrolase. bioRxiv (2021).
18. Paper Recent progress of protein structure calculation by solution NMR. Agri Bio (2021).
19. Paper Recent progress of protein structure calculation by solution NMR. Saibou 53, 48–52 (2021).
20. Paper Protein structure determination in living cells from NOE-derived distance restraints. New Developments in NMR 2020-(21), 65–89 (2020).
21. Paper NMRによる生体高分子立体構造計算の基礎と最近の進展．日本核磁気共鳴学会学会誌 (2019).
22. Paper Paramagnetic relaxation enhancement-assisted structural characterization of a partially disordered conformation of ubiquitin. Protein Science 28(11), 1993–2003 (2019).
23. Paper Protein Structure Determination in Living Cells. International Journal of Molecular Sciences 20(10), 2442 (2019).
24. Paper High-Resolution Protein 3D Structure Determination in Living Eukaryotic Cells. Angewandte Chemie International Edition 58(22), 7284–7288 (2019).
25. Paper New Developments in MMR Series: In-cell NMR Spectroscopy: From Molecular Sciences to Cell Biology. The Royal Society of Chemistry (2019).
26. Paper Solution NMR views of dynamical ordering of biomacromolecules. Biochimica et Biophysica Acta (BBA) – General Subjects 1862(2), 287–306 (2018).
27. Paper Protein NMR Structure Refinement Based on Bayesian Inference for Dynamical Ordering of Biomacromolecules. Journal of Computer Chemistry, Japan 17(1), 65–75 (2018).
28. Paper Advances in NMR data acquisition and processing for protein structure determination. Experimental Approaches of NMR Spectroscopy, 63–90 (2017).
29. Paper Experimental approaches of NMR spectroscopy. Springer (2017).
30. Paper Improved in-cell structure determination of proteins at near-physiological concentration. Scientific Reports 6 (2016).
31. Paper A specific single-stranded DNA induces a distinct conformational change in the nucleoid-associated protein HU. Biochemistry and Biophysics Reports 8, 318–324 (2016).
32. Paper A new carbamidemethyl-linked lanthanoid chelating tag for PCS NMR spectroscopy of proteins in living HeLa cells. Journal of Biomolecular NMR 66(2), 99–110 (2016).
33. Paper Protein NMR Structure Refinement based on Bayesian Inference. Journal of Physics: Conference Series 699(1), 012005 (2016).
34. Paper Application of Sparse Modeling to Biological NMR. The Journal of the Institute of Electronics, Information and Communication Engineers 99(5), 439–443 (2016).
35. Paper Evaluation of the reliability of the maximum entropy method for reconstructing 3D and 4D NOESY-type NMR spectra of proteins. Biochemical and Biophysical Research Communications 457(2), 200–205 (2015).
36. Paper Automated resonance assignment of the 21 kDa stereo-array isotope labeled thiol-disulfide oxidoreductase DsbA. Journal of Magnetic Resonance 249, 88–93 (2014).
37. Paper Influence of NMR Data Completeness on Structure Determinations of Homodimeric Proteins. Journal of the Chinese Chemical Society 61(12), 1297–1306 (2014).
38. Paper An in-cell NMR study of monitoring stress-induced increase of cytosolic Ca²⁺ concentration in HeLa cells. Biochemical and Biophysical Research Communications 438(4), 653–659 (2013).
39. Paper NMR Solution Structure of a Chymotrypsin Inhibitor from the Taiwan Cobra Naja naja atra. Molecules 18(8), 8906–8918 (2013).
40. Paper 蛋白質機能における構造–ダイナミクス–安定性の関係：In-cell NMRからわかること．生物物理 53(2), 76–81 (2013).
41. Paper High-Resolution Heteronuclear Multidimensional NMR of Proteins in Living Insect Cells Using a Baculovirus Protein Expression System. Journal of the American Chemical Society 135(5), 1688–1691 (2013).
42. Paper Exclusively NOESY-based automated NMR assignment and structure determination of proteins. Journal of Biomolecular NMR 50(2), 137–146 (2011).
43. Paper Structural investigation of the C-terminal catalytic fragment of presenilin 1. Proceedings of the National Academy of Sciences 107(21), 9644–9649 (2010).
44. Paper NMR protein structure determination in living E. coli cells using nonlinear sampling. Nature Protocols 5(6), 1051–1060 (2010).
45. Paper Conformational stability and activity of p73 require a second helix in the tetramerization domain. Cell Death & Differentiation 16(12), 1582–1589 (2009).
46. Paper Automated NMR structure determination of stereo-array isotope labeled ubiquitin from minimal sets of spectra using the SAIL-FLYA system. Journal of Biomolecular NMR 44(4), 261–272 (2009).
47. Paper Protein structure determination in living cells by in-cell NMR spectroscopy. Nature 458(7234), 102–U10 (2009).
48. Paper Structure of the putative 32 kDa myrosinase-binding protein from Arabidopsis (At3g16450.1) determined by SAIL-NMR. FEBS Journal 275(23), 5873–5884 (2008).
49. Paper Solution structure of the C-terminal dimerization domain of SARS coronavirus nucleocapsid protein solved by the SAIL-NMR method. Journal of Molecular Biology 380(4), 608–622 (2008).
50. Paper Automated structure determination of proteins with the SAIL-FLYA NMR method. Nature Protocols 2(11), 2896–2902 (2007).
51. Paper Evaluation of stereo-array isotope labeling (SAIL) patterns for automated structural analysis of proteins with CYANA. Magnetic Resonance in Chemistry 44, S152–S157 (2006).
52. Paper Heteronuclear multidimensional NMR and homology modelling studies of the C-terminal nucleotide-binding domain of the human mitochondrial ABC transporter ABCB6. Journal of Biomolecular NMR 35(1), 53–71 (2006).
53. Paper Design of lambda Cro fold: Solution structure of a monomeric variant of the de novo protein. Journal of Molecular Biology 354(4), 801–814 (2005).
54. Paper Molecular analysis of genes expressed during the calcification of the exoskeleton of the decapod crustacean Penaeus japonicus, in Biomineralization: Formation, Diversity, Evolution and Application. Tokai University Press, 149–152 (2003).
55. Paper The DD5 gene of the decapod crustacean Penaeus japonicus encodes a putative exoskeletal protein with a novel tandem repeat structure. Comparative Biochemistry and Physiology Part B 128(3), 379–388 (2001).
56. Paper Formation of the Calcified Exoskeleton in the Prawn, Penaeus japonicus. In Calcium Metabolism: Comparative Endocrinology. BioScientifica Ltd, Bristol, 1–6 (1999).
57. Book Experimental approaches of NMR spectroscopy -Methodology and application to life science and materials science 2nd Ed. Springer (2025).
58. Book 生命金属ダイナミクス : 生体内における金属の挙動と制御．エヌ・ティー・エス (2021).
59. Book 計算シミュレーションと分析データ解析．丸善 (2007).
60. Book バイオインフォマティクスコンピューティング．オーム社 (2004).
61. Book Experimental approaches of NMR spectroscopy -Methodology and application to life science and materials science 2nd Ed. Springer (2025).
62. Book 生命金属ダイナミクス : 生体内における金属の挙動と制御．エヌ・ティー・エス (2021).
63. Book 計算シミュレーションと分析データ解析．丸善 (2007).
64. Book バイオインフォマティクスコンピューティング．オーム社 (2004).

　　
• ■　Organic Structure Biochemistry Laboratory (OSBC) TOP

　　
• ■　Tokyo Metropolitan University Top

　　
• ■　Graduate School of Science and Engineering

　　
• ■　Department of Chemistry

　　

　　
• ■　Goethe Univ. Frankfurt, Guentert Lab.

　　
• ■　The University of Tokyo, Agricultural and Life Sciences, BILAB

　　
• ■　The SAIL (Stereo Array Isotope Labelling) Wiki

　　
• ■　SAIL Technologies Inc.

　　
• ■　Computational Biology Research Center (CBRC)

　　

　　
• ■　The Nuclear Magnetic Resonance Society of Japan

　　
• ■　Protein Science Society of Japan

　　
• ■　The Biophysical Society of Japan

　　
• ■　The Japanese Biochemical Society

　　
• ■　The Molecular Biology Society of Japan

　　
• ■　The Chemical Society of Japan

　　
• ■　The Institute of Electronics, Information and Communication Engineers

　　
• ■　International Society for Magnetic Resonance (ISMAR)

　　
• ■　International Conference of Magnetic Resonance in Biological Systems